20th World Conference on Pharmaceutical Chemistry and Drug Design

             CHEMOINFORMATICS IN DRUG DISCOVERY & DEVELOPMENT Due to the complex structures of biomolecules which are responsible for disease such as AIDS, Cancer, Autism, Alzheimer etc. discovery of drugs still remains a challenging task for medical researchers. Due to changes in various factors which includes food habit, environmental and migration in human life style it has become mandatory in recent times to design and develop a drug without any side effects. Cheminformatics deals with discovering drugs based in modern drug discovery techniques which in turn rectifies complex issues in traditional drug discovery system. For better understanding of complex structures of chemical compounds cheminformatics tools are most prominent. Cheminformatics drug Discovery is a new emerging interdisciplinary field which primarily aims to discover Novel Chemical Entities which ultimately results in design of new molecule. It also plays an i...

                       Marine Pharmacology in Drug Discovery and Development New diseases are emerging due to the changes in the environments. Overburdened is created for the existing resources for the drugs due to enormous growth of world population. Though 75% of earth's surface is covered by water the research on pharmacology of marine organisms is limited and remained unexplored. Marine environment gives countless and diverse resources for the development of new drugs against cancer or malaria. The aquatic organisms are screened for antibacterial, immunomodulator, anti-fungal, anti-inflammatory, anticancer, antimicrobial, neuroprotective, analgesic, and antimalarial properties are used for the new drug developments throughout the world. Marine pharmacology offers the scope for research on Drugs Discovery and Development from marine origin. Marine pharmacology is a branch of pharmaceutical sciences which focuses o...

     DNA Drug Design for Cancer Therapy A direct genetic approach for cancer treatment is represented through DNA (antisense and other oligonucleotides (ODN’s)) drug design . This approach follows the mechanisms that activate genes known to confer a growth advantage to neoplastic cells. They have the ability to block the expression of these genes which allows exploration of normal growth regulation. As the Progress in DNA drug technology has been rapid, the traditional antisense inhibition of gene expression is now viewed on a genomic scale. Several antisense oligonucleotides are in clinical trials. These antisense oligonucleotides are well tolerated, and are potentially, therapeutically active. These drugs are promising molecular medicines for the treatment of human cancer in the near future. Antisense or decoy DNA drugs can specifically inhibit gene expression and, as indicated in this review, can ultimately affect abnormal cell proliferation. Downregulat...