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CANCER GENOMICS FOR MEDICINAL CHEMISTRY

Malignancy is a hereditary infection. Malignant growth genomics is to methodically arrangement of the genome with the end goal to distinguish repetitive genomics changes in tumors. To date, in excess of 80 kinds of malignant growths are, or have been, sequenced by revolves far and wide. These undertakings have extended the rundown of disease qualities and furthermore uncovered many developing dysregulated cell procedures, for example, those engaged with chromatin and epigenomic control, and also those that are associated with RNA grafting, protein homeostasis, digestion and heredity development. The quick development in disease genomics research can be to a great extent ascribed to the utilization of novel cuttingedge sequencing advancements and the improvement of new drug discovery approaches. Computational instruments empower the incredible investigation of expansive volume of malignant growth genomics information to more readily comprehend the…
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Current Trends in Clinical Trials




Clinical Trials are the studies which covers high quality manuscripts both relevant and applicable to the broad field of experiments or observations done in clinical research. These studies renders novel, clear connection with clinical practitioners, medical/ health practitioners, students, professionals, researchers, professional bodies and institutions.



Focus and Scope Currently Clinical Trials objective is to maintain and develop science and related research at an international level. It is important to bring into light of outstanding research and development results to the world instantaneously in latest advancements towards clinical trials to achieve objective of the clinical trials.
Highlighted Topics • Adverse Event Monitoring • Biomarkers in Clinical Trials • Biostatistics • Cancer Clinical Trials • Clinical Case Studies • Clinical Practice Guidelines • Clinical Progress for Specific Diseases or Therapeutic Areas
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Pharmacovigilance in Drug Discovery

The increased use of novel, accelerated regulatory pathways had given a dramatic impact on the role of pharmacovigilance in drug development.
During the past 10 days, there is a decrease in time taken to bring new drugs to market. While this acceleration has increased the detection of the risk of adverse drug reactions only when the product is already in the market, leading to higher demand for post-approval safety surveillance studies and related activities.
The move from paper to electronic formats and with increased vigilance has increased the amount and velocity of safety information in the environment. The evaluation of cases at point of initial entry needs to be undertaken at the highest standard of both quality and timeliness—despite ever-increasing volumes.
The pharmacological science which deals with drug safety including accumulation, detection, assessment, monitoring, and prevention of adverse effects of the drugs is Pharmacovigilance. It foc…
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CHEMOINFORMATICS IN DRUG DISCOVERY & DEVELOPMENT


Due to the complex structures of biomolecules which are responsible for disease such as AIDS, Cancer, Autism, Alzheimer etc. discovery of drugs still remains a challenging task for medical researchers. Due to changes in various factors which includes food habit, environmental and migration in human life style it has become mandatory in recent times to design and develop a drug without any side effects. Cheminformatics deals with discovering drugs based in modern drug discovery techniques which in turn rectifies complex issues in traditional drug discovery system. For better understanding of complex structures of chemical compounds cheminformatics tools are most prominent. Cheminformatics drug Discovery is a new emerging interdisciplinary field which primarily aims to discover Novel Chemical Entities which ultimately results in design of new molecule. It also plays an important role for collecting, storing and analyzing the chemical d…
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                       Marine Pharmacology in Drug Discovery and Development

New diseases are emerging due to the changes in the environments. Overburdened is created for the existing resources for the drugs due to enormous growth of world population. Though 75% of earth's surface is covered by water the research on pharmacology of marine organisms is limited and remained unexplored. Marine environment gives countless and diverse resources for the development of new drugs against cancer or malaria. The aquatic organisms are screened for antibacterial, immunomodulator, anti-fungal, anti-inflammatory, anticancer, antimicrobial, neuroprotective, analgesic, and antimalarial properties are used for the new drug developments throughout the world. Marine pharmacology offers the scope for research on Drugs Discovery and Development from marine origin. Marine pharmacology is a branch of pharmaceutical sciences which focuses on the substances with active pharmacological properties present in …
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DNA Drug Design for Cancer Therapy
A direct genetic approach for cancer treatment is represented through DNA (antisense and other oligonucleotides (ODN’s)) drug design. This approach follows the mechanisms that activate genes known to confer a growth advantage to neoplastic cells. They have the ability to block the expression of these genes which allows exploration of normal growth regulation. As the Progress in DNA drug technology has been rapid, the traditional antisense inhibition of gene expression is now viewed on a genomic scale. Several antisense oligonucleotides are in clinical trials. These antisense oligonucleotides are well tolerated, and are potentially, therapeutically active. These drugs are promising molecular medicines for the treatment of human cancer in the near future.
Antisense or decoy DNA drugs can specifically inhibit gene expression and, as indicated in this review, can ultimately affect abnormal cell proliferation. Downregulation of genes that contribute to canc…
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Nano-Technology in Drug Discovery  & Development
The Technology which uses creation and utilization of materials, devices and systems through the control of matter on the nanometer scale is called Nano-technology. Impact on diagnostics and drug delivery is created by the application of nanotechnology in life sciences, nanobiotechnology. Now, researchers are started using Nano-technology (including nanoparticles and nanodevices such as Nano-biosensors and Nano-biochips) in the field of drug discovery and development. Nano-substances could be potential drugs for the future. Safety concerns, determining the nature and extent of adverse events of drugs are determined by the use of Nano-technology.Nanotechnology applications in healthcare and for the development of personalized medicine appear to be excellent. Analyses of signaling pathways by nanobiotechnology techniques provides new insights into disease processes by identifying biomarkers and understanding the mechanisms of action of …