Chemical biology of Neuroprotection

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Neuroprotection portrays one of the most captivating therapeutic strategies for the prevention of neurodegeneration and attenuating neuronal damage. The evolution of novel neuroprotective agents has attracted stupendous drug discovery efforts, aiming towards the identification of effective neurotherapeutics for a number of central nervous system (CNS) disorders, including neurodegenerative diseases such as Alzheimer's disease (AD),  Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), dementia, stroke, traumatic brain injury (TBI), spinal cord injury, schizophrenia, drug abuse-induced neurotoxicity (i.e. methamphetamine overdoses), and even retinal diseases and glaucoma. This  aims to provide a forum for the dissemination of the latest information on new molecules including both synthetic compounds and natural products as well as novel drug targets associated with neuroprotective agents and to appeal all neuropharmacologists, chemical biologists, medicinal chemists, and other researchers interested in neuroprotective agent drugdiscovery and development and neuroprotection, to enlighten us by being a part of 20th World Conference on Pharmaceutical Chemistry and Drug Design to be held on September 03-05, 2018 at Dubai, UAE. Enclosed under the theme “Exceeding the Vision in Drug and Pharmaceutical Chemistry”

Neuroprotection can further be explained as the relative preservation of neuronal structure and function. In the case of a neurodegenerative insult the relative preservation of neuronal integrity implicit the rate reduction of neuronal loss across time. Neuroprotection directs to arrest or lower the disease progression and further secondary lacerations by halting or by lowering the neuronal loss.

In spite of differences in indications or injuries corresponded with CNS disorders, most of the mechanisms are similar beneath neurodegeneration. Few of these mechanisms cover mitochondrial dysfunction, increased levels in oxidative stress, inflammatory changes, excitotoxicity, protein aggregation and iron accumulation. Among these mechanisms, neuroprotective treatments often target excitotoxicity and oxidative stress because both the mechanisms are highly related with the disorders of Central Nervous System. Combination of both excitotoxicity and oxidative stress can be hilarious as when combined they trigger major neuronal loss and ultimately death of neuron cells due to synergistic effects. That is why limiting oxidative stress and excitotoxicity is a very essential feature of Neuroprotection.


Roza Palv
Program Manager-Pharma Chem 2018
Contact: pharmaceuticalchemistry@pharmameetings.com

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