Chemical biology of Neuroprotection

-

                                                                                
Neuroprotection portrays one of the most captivating therapeutic strategies for the prevention of neurodegeneration and attenuating neuronal damage. The evolution of novel neuroprotective agents has attracted stupendous drug discovery efforts, aiming towards the identification of effective neurotherapeutics for a number of central nervous system (CNS) disorders, including neurodegenerative diseases such as Alzheimer's disease (AD),  Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), dementia, stroke, traumatic brain injury (TBI), spinal cord injury, schizophrenia, drug abuse-induced neurotoxicity (i.e. methamphetamine overdoses), and even retinal diseases and glaucoma. This  aims to provide a forum for the dissemination of the latest information on new molecules including both synthetic compounds and natural products as well as novel drug targets associated with neuroprotective agents and to appeal all neuropharmacologists, chemical biologists, medicinal chemists, and other researchers interested in neuroprotective agent drugdiscovery and development and neuroprotection, to enlighten us by being a part of 20th World Conference on Pharmaceutical Chemistry and Drug Design to be held on September 03-05, 2018 at Dubai, UAE. Enclosed under the theme “Exceeding the Vision in Drug and Pharmaceutical Chemistry”

Neuroprotection can further be explained as the relative preservation of neuronal structure and function. In the case of a neurodegenerative insult the relative preservation of neuronal integrity implicit the rate reduction of neuronal loss across time. Neuroprotection directs to arrest or lower the disease progression and further secondary lacerations by halting or by lowering the neuronal loss.

In spite of differences in indications or injuries corresponded with CNS disorders, most of the mechanisms are similar beneath neurodegeneration. Few of these mechanisms cover mitochondrial dysfunction, increased levels in oxidative stress, inflammatory changes, excitotoxicity, protein aggregation and iron accumulation. Among these mechanisms, neuroprotective treatments often target excitotoxicity and oxidative stress because both the mechanisms are highly related with the disorders of Central Nervous System. Combination of both excitotoxicity and oxidative stress can be hilarious as when combined they trigger major neuronal loss and ultimately death of neuron cells due to synergistic effects. That is why limiting oxidative stress and excitotoxicity is a very essential feature of Neuroprotection.


Roza Palv
Program Manager-Pharma Chem 2018
Contact: pharmaceuticalchemistry@pharmameetings.com

Comments

Post a Comment

Popular posts from this blog

Nanomedicine & Women’s Health

-
Image
Nanomedicine have the potential to revolutionize the diagnosis, prevention, and treatment of a range of conditions and diseases affecting women’s health Nanomedicine is the application of  nanotechnology  in the field of medicine with a view to enhancing the diagnosis and treatment of various diseases. Nanotechnology is already involved in a range of biomedical applications including drug and vaccine delivery, diagnostic imaging, nanosensor diagnostics, nano-enabled therapies, and tissue engineering. A growing recognition of the specific health care requirements of women has resulted in the proposed organizational changes in the provision of health care, focusing predominantly on a life course approach to women’s health care. As our understanding of the benefits of nanomaterial-based agents and diagnostics continues to grow in terms of selectivity, sensitivity, affinity, and detection limits, there is a widespread anticipation that nanotechnology will play an increasing rol
Read more

Drug Development with Translational Pharmaceutics

-
Image
As the   pharmaceutical   industry faces increasing pressure to accelerate drug development, many contract development organizations are recommending early development programs.   Scientists discussed the current roadblocks in the traditional   drug development   process and explains how productivity can be improved and timelines shortened by implementing a new approach the company refers to as Translational Pharmaceutics.   Be the part of   20th World Conference on Pharmaceutical Chemistry and Drug Design   in Dubai, UAE during September 03-05, 2018. Describe the state of affairs of researches, thesis, projects and enlighten us with your innovation and meet pharmacists, apothecaries, druggists, scientists, experts and technologists. https://drug-chemistry.pharmaceuticalconferences.com There are many factors that can delay the development and eventual commercialization of   novel therapeutics . One of the most intractable factors is the conventional trial-and-error approach
Read more

20th World Conference on Pharmaceutical Chemistry and Drug Design

-
Image
Drug design is an inventive process of medication discovered by biological target. It is also known as rational drug design or rational design. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense. Drug design relies on the knowledge of the three-dimensional structure of bioactive sites. The drug is an active molecule, when it is predicament to target site it can either inhibit or activate the function of a biomolecule which effects in therapeutic benefit. The main objective in drug design is to foresee whether a given particle will bind to a target and if so how unequivocally. Molecular mechanics or molecular dynamics are regularly used to predict the conformation of the little particle and to model conformational changes in the biological targets that may happen when the little molecules ties to it.   The us
Read more