DRUG EFFECTING THE DRUG RESISTANCE PATHOGENS

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  A molecule called Lip oxazolidinone A is a synthetic compound could be used as a tool for the study of infectious agents, especially gram positives might find its application in the future drug creations. It is isolated from bacteria found in the marine sediments. Hence it is obtained from natural product. These bacteria produces the secondary metabolites, which is used for purposes like defense. During the initial isolation of lip oxazolidinone A was found to be effective against Gram-positive bacteria like MRSA. These original findings were confirmed and understood to correlate the molecular structure to its function, to know the portions of it was responsible for its anti-microbial actions and to improve that structure. Lip oxazolidinone A was synthesized using the novel chemical tools in the lab. It helped to confirm the portion of the structure responsible for an antibiotic reaction which was JJM35. It was tested on both the resistant and non-resistant strains of bacteria. It was tested invitro against MRSA showed   that the molecule was 50 times more effective against several bacterial strains compared to other natural drug. In Addition to this, it was effective against resistant bacterial strains than nonresistant strains. It was identified that these molecules might also inhibit multiple biosynthetic pathways directly or indirectly which means bacteria may have difficulty in developing resistance to potential drugs obtained from these molecules. The chemical scaffold obtained is evaluated for knowing in-vivo efficacy of the molecule. This scaffold is built in order to synthesize drugs   effective against MRSA and other resistant bacteria and also to increase their spectrum of activity.


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