Prominent drugs with less side effects


Chemical compounds are made up of molecules. Chiral molecules are one of the most important molecules in biology. Meaning of Chiral in Greek represents the hand which describes that molecules that almost exactly looks alike and contain the same number of atoms but are mirror images of one another which means some are "left-handed" and others are "right-handed." This difference is crucial and yields different biological effects. The differences of the Chiral was made clear by drug thalidomide. It was later marketed to pregnant women in the late 1950’s and 1960’s to get relief from morning sickness. However, thalidomide is a chiral drug, the “right” chiral molecule of it causes relief from morning sickness and its “left” chiral molecule caused deformities in babies. Since the left chiral molecule was not separated from the right chiral molecule in thalidomide by the drug company, it resulted in huge effect to the babies inside the womb. The separation of chiral molecules into their right and left chiral components becomes very expensive procedure and needs tailor made approach for each of the molecule. Now, however, by the series of research undertaken, uniform, generic method is undertaken which will enable pharmaceutical and chemical manufactures to cheaply delete the left chiral molecule to reduce the side effects. The method is based on magnets. Chiral molecules attract to the magnetic substrate and line up according to the direction of their right and left handedness. Left chiral molecules is attracted to one pole of the magnet and right molecule to the other pole. This process allows the chemical manufacturers to discard the left molecule and retain the right molecule which reduces the side effect. Some of the popular drugs like Ritalin and Cipramil are sold in their chirally pure form, while many of the generic medicines are not. Though it has been recommended by the FDA, only 1e% of the chiral drugs are been separated as of now. Chirally-pure pesticides and fertilizers needs smaller doses in the field of agrochemicals which leads to less environmental contamination when compared to their unseparated counterparts. With these statistics the simple and cost effective chiral separation process is able to produce better medical and agricultural products, including drugs, food ingredients, dietary supplements and fertilizers.


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