-

    Nano-Technology in Drug Discovery  & Development

                                                          


The Technology which uses creation and utilization of materials, devices and systems through the control of matter on the nanometer scale is called Nano-technology. Impact on diagnostics and drug delivery is created by the application of nanotechnology in life sciences, nanobiotechnology. Now, researchers are started using Nano-technology (including nanoparticles and nanodevices such as Nano-biosensors and Nano-biochips) in the field of drug discovery and development. Nano-substances could be potential drugs for the future. Safety concerns, determining the nature and extent of adverse events of drugs are determined by the use of Nano-technology.Nanotechnology applications in healthcare and for the development of personalized medicine appear to be excellent.
Analyses of signaling pathways by nanobiotechnology techniques provides new insights into disease processes by identifying biomarkers and understanding the mechanisms of action of drugs. which will help in designing new approaches to drug discovery. Various fundamental nanotechnologies and nanodevices are used in drug discovery. Technologies like nanoscale miniaturizations of microfluidic used in proteomics.

Nanotechnologies:
  • ·         High-field asymmetric waveform ion mobility spectrometry
  • ·         Investigating biomolecular interactions with atomic force Microscopy
  • ·         Examining molecular reactions and interactions using cantilevers
  • ·         Assays based on endocytosis at the nanoscale
  • ·         Surface plasmon resonance
  • ·         Nanoflow liquid chromatography
  • ·         Fluorescence planar wave guide technology

Nanowire devices:
  • ·         Biosensors
  • ·         Nano-wire devices
  • ·         Nano-fluidics,
  • ·         Nano-arrays
  • ·         Nano-biochips

Nanomaterials as drug candidates:
  • ·         Dendrimers
  • ·         Fullerenes

Future of nanotechnology-based drug discovery:

Nano-biotechnology applications in pharmaceutical and biotechnology industries is anticipated. several other nanotechnologies are in development for use in life sciences from innovations based on Nano-particles. In future, it might be possible to accurately model the structure of an individual cell and to predict its function using computers connected to nanobiotechnology systems. Such a detailed virtual representation of how a cell functions might enable scientists to develop novel drugs with unprecedented speed and precision, without doing any experiments on living animals.

Nanotechnology can be applied at all stages of drug development, from formulations for optimal delivery to diagnostic applications in clinical trials. It will fit in with the concepts for the integration of diagnostics and therapeutics to develop personalized medicine.





Comments

Post a Comment

Popular posts from this blog

Nanomedicine & Women’s Health

-
Image
Nanomedicine have the potential to revolutionize the diagnosis, prevention, and treatment of a range of conditions and diseases affecting women’s health Nanomedicine is the application of  nanotechnology  in the field of medicine with a view to enhancing the diagnosis and treatment of various diseases. Nanotechnology is already involved in a range of biomedical applications including drug and vaccine delivery, diagnostic imaging, nanosensor diagnostics, nano-enabled therapies, and tissue engineering. A growing recognition of the specific health care requirements of women has resulted in the proposed organizational changes in the provision of health care, focusing predominantly on a life course approach to women’s health care. As our understanding of the benefits of nanomaterial-based agents and diagnostics continues to grow in terms of selectivity, sensitivity, affinity, and detection limits, there is a widespread anticipation that nanotechnology will play an increasing rol
Read more

Drug Development with Translational Pharmaceutics

-
Image
As the   pharmaceutical   industry faces increasing pressure to accelerate drug development, many contract development organizations are recommending early development programs.   Scientists discussed the current roadblocks in the traditional   drug development   process and explains how productivity can be improved and timelines shortened by implementing a new approach the company refers to as Translational Pharmaceutics.   Be the part of   20th World Conference on Pharmaceutical Chemistry and Drug Design   in Dubai, UAE during September 03-05, 2018. Describe the state of affairs of researches, thesis, projects and enlighten us with your innovation and meet pharmacists, apothecaries, druggists, scientists, experts and technologists. https://drug-chemistry.pharmaceuticalconferences.com There are many factors that can delay the development and eventual commercialization of   novel therapeutics . One of the most intractable factors is the conventional trial-and-error approach
Read more

20th World Conference on Pharmaceutical Chemistry and Drug Design

-
Image
Drug design is an inventive process of medication discovered by biological target. It is also known as rational drug design or rational design. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense. Drug design relies on the knowledge of the three-dimensional structure of bioactive sites. The drug is an active molecule, when it is predicament to target site it can either inhibit or activate the function of a biomolecule which effects in therapeutic benefit. The main objective in drug design is to foresee whether a given particle will bind to a target and if so how unequivocally. Molecular mechanics or molecular dynamics are regularly used to predict the conformation of the little particle and to model conformational changes in the biological targets that may happen when the little molecules ties to it.   The us
Read more