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                           NATURAL PRODUCTS IN DRUG DISCOVERY PROCESS
Natural products have historically been incredible as a source of therapeutic agents in curing many diseases. In last 10 years, research on natural products in the pharmaceutical field has reduced, owing to issues such as the lack of compatibility of traditional natural-product extract libraries with high-throughput screening. Recent techniques in genomics, proteomics and structural biology during the past few decades are giving a clearer picture of the diversity of proteins targeted by natural-product molecules. The current lead generation strategies have led to a renewed interest in natural products in drug discovery.
There is need of drug discovery process and new drug designing techniques due to prevalence of many diseases without suitable medical products available. The Research and Development process is one of the pioneer processes to save the therapeutic innovation, following three key technologies have been introduced.
·         High Throughput Screening (HTS)
·         Combinatorial Chemistry
Types Of Sources For Natural Products For Drug Discovery:
Despite the rise of combinatorial chemistry as an integral part of drug discovery process, natural products still play a prominent role as starting material for drug discovery. Drug product have been obtained from various sources which include plants, animal, marine and microbial metabolites.

 Natural Product Discovery Approaches

Screening of natural product extracts is complicated due to the presence of fluorescent or insoluble compounds. Advances in detection technologies and new screening assays have overcome many of these challenges. Following are the approaches for drug discovery:

·         Cell-Based Assays

·         Biochemical Assays

·         Newer Drug Discovery

New Trends In Field Of Natural Product Drug Discovery

The processes of drug discovery from natural products have been modified by some new advances:

·         Preparation of pure compounds from a crude extract by preparative HPLC extract by iterative HPLC.

·         After HPLC separation, On-line multi pharmacological detections are possible which allow parallel flow bioassay lines for biological activity, selectivity analyses and spectrometric data in order to obtain structural information.

·         Progress in metabolomics will soon permit to predict the chemical composition of a plant extract through the genome, transcriptome and proteome (enzymes) data.

 Natural products are the building blocks for molecular libraries. The confluence of technologies with advancements in genomics, proteomics, metabolic engineering and chemical synthesis offers the new method along with the technologies to explore the remarkable chemical diversity of nature’s ‘small molecules’ in the pursuance for new drugs.

 

 

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https://drug-chemistry.pharmaceuticalconferences.com/

 

 

 

 

 

 

 

 

 


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