20th World Conference on Pharmaceutical Chemistry and Drug Design

                                                                                 Neuroprotection portrays one of the most captivating therapeutic strategies for the prevention of neurodegeneration and attenuating neuronal damage. The evolution of novel neuroprotective agents has attracted stupendous drug discovery efforts, aiming towards the identification of effective neurotherapeutics for a number of central nervous system (CNS) disorders, including neurodegenerative diseases such as Alzheimer's disease (AD),   Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), dementia, stroke, traumatic brain injury (TBI), spinal cord injury, schizophrenia, drug abuse-induced neurotoxicity (i.e. methamphetamine overdoses), and even retinal diseases and glaucoma. This ...

20th World Conference on Pharmaceutical Chemistry and Drug Design The principles governing drug targeting in anti-cancer chemotherapy to achieve a tumor-specific targeting are the enzyme responsible for prodrug activation should uniquely be present in the tumor cell. Although there is much evidence of pathways involving enzymes that are aberrantly expressed in tumors, these approaches have found varying success because the differences between healthy and tumor tissues are not normally consistent across different species, individuals, or even tumors. Hypoxia is a common and unique property of cells in solid tumors, and it is therefore a potential mechanism for tumor-specific prodrug activation. The availability of oxygen electrodes has allowed the accurate measurement of oxygen levels in human tumors, which are highly heterogeneous. Polymer-directed enzyme prodrug therapy is a two-step antitumor approach that uses a combination of a polymeric prodrug and a polymer-enzyme conjug...

                      In the domain of Pharmaceutical chemistry, biotechnology and medicine, Drug discovery can be defined as an approach to discover new medications or candidate medications. In early days these medications and drugs were identified by discovering the active ingredient with the help of traditional remedies. In history drugs were nothing but the plant extracts, minerals and materials of animal origin. The process of drug discovery involves a melding of many disciplines and interests, transcending the relatively simple process of identifying an active compound in the test tube. The discovery of a novel chemical entity that modulates some aspect of cell or tissue function is but the first step in the drug development process. Once shown to be selective and efficacious, a compound must also be relatively free of toxicity, bioavailable, and marketable before it can be considered as a therapeutic entity. In...

                                         The Present Marketing practice in the Pharmaceutical sector, examining both customer and doctor slanted towards promotion. The present examples of marketing practices and their impact on consumer and doctor behavior. It identifies negative impact of these practices which include misleading advertising, disease shove and escalating costs. It goes on to maintain the need for an independently monitored code of practice for marketers in the pharmaceutical sector and a great degree of consumer education for both end users and those Prescribing drugs Drug specialists or a drug specialist right hand can prompt shoppers on which things to purchase for particular therapeutic conditions or human services needs. A drug specialist is accountable for the drug store and needs to ensure that every patient gets the best possible prescription, the bes...

                                       Nanotechnology has now introduced to develop medicine. Nanotechnology contains the use of materials with essential length scales in the nanometer measurement which demonstrate significantly changed properties associated to micron structured materials. Such materials can include particles, fibers, grain sizes, etc. This session highlighted the progressions nanotechnology is making in medicine in such fields as disease prevention, diagnosis, and treatment including (but not limited to) drug delivery, tissue engineering, implants, sensors, cancer treatment, an but not limited to) drug delivery, tissue engineering, transplants, sensors, cancer treatment, and toxic. Nanotechnology is the term given to those regions of science and building where marvels that happen at measurements in the nanometre scale are used in the plan, characterisation, gene...

                                                                                                       The term drug targets regularly used in medicinal research to describe the native protein in the body whose activity is modified by a drug resulting in a distinct effect, which may be a desirable therapeutic effect or an unwanted side effect. In this context, the biological target is often referred to as a biological target. The most common drug targets are G-protein couple receptor, enzymes, ligand gated channels, voltage gated channels, ion channels, nuclear hormone receptor and membrane transport proteins Target discovery, which includes the distinguishing proof and early approval of infection changing targets, is...

Drug design is an inventive process of medication discovered by biological target. It is also known as rational drug design or rational design. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense. Drug design relies on the knowledge of the three-dimensional structure of bioactive sites. The drug is an active molecule, when it is predicament to target site it can either inhibit or activate the function of a biomolecule which effects in therapeutic benefit. The main objective in drug design is to foresee whether a given particle will bind to a target and if so how unequivocally. Molecular mechanics or molecular dynamics are regularly used to predict the conformation of the little particle and to model conformational changes in the biological targets that may happen when the little molecules ties to it.   Th...