20th World Conference on Pharmaceutical Chemistry and Drug Design

Oral delivery method of Insulin can change the whole view of controlling the diabetes and keep updating about one’s blood sugar level. It has promise to give a good quality of life up to 40million people with type 1 diabetes.   It also overcomes the side effects faced by the patients when they are unable to inject with insulin. Insulin is just injected to the subcutaneous layer of skin which is usually used therapy to check the blood sugar level, but many fail due to pain, phobia of needles etc. As insulin is a protein, when it enters orally it reacts with the stomach's acidic environment and it is partially absorbed out of the intestine. This approach is adopted by inserting insulin in an ionic liquid which is composed of choline and geranic acid which is later filled inside a capsule with an acid-resistant enteric coating. The orally available insulin thus is biocompatible, easy to produce and has longer shelf life than the market available injectable insulin. The ins...

There is a linked sensitivity to an allergen called galactose-α-1,3-galactose, or alpha-Gal , a type of complex sugar which causes allergy in the red meat and builds up plaque in the arteries of the heart. High saturated fat present in red meat is known to cause heart disease in humans. The population is at a risk of this food allergen.  The first such kind of allergy was found among the small population in Virginia. These findings needs further clinical studies among large group of populations which differ from the geographical locations and a lot of other laboratory techniques. Large percent of human population develops blood antibodies to this allergen which shows less symptoms around 20 percent among the population. The Lone Star tick was found in red meat, when it bites it sensitizes the allergen and produce allergy. The allergy increases based on the area  where the ticks were found in large numbers for example Southeastern United States, but also found in some...

   A molecule called Lip oxazolidinone A is a synthetic compound could be used as a tool for the study of infectious agents, especially gram positives might find its application in the future drug creations. It is isolated from bacteria found in the marine sediments. Hence it is obtained from natural product. These bacteria produces the secondary metabolites, which is used for purposes like defense. During the initial isolation of lip oxazolidinone A was found to be effective against Gram-positive bacteria like MRSA. These original findings were confirmed and understood to correlate the molecular structure to its function, to know the portions of it was responsible for its anti-microbial actions and to improve that structure. Lip oxazolidinone A was synthesized using the novel chemical tools in the lab. It helped to confirm the portion of the structure responsible for an antibiotic reaction which was JJM35 . It was tested on both the resistant and non-resistant strains ...

Chemical compounds are made up of molecules. Chiral molecules are one of the most important molecules in biology. Meaning of Chiral in Greek represents the hand which describes that molecules that almost exactly looks alike and contain the same number of atoms but are mirror images of one another which means some are "left-handed" and others are "right-handed." This difference is crucial and yields different biological effects. The differences of the Chiral was made clear by drug thalidomide . It was later marketed to pregnant women in the late 1950’s and 1960’s to get relief from morning sickness. However, thalidomide is a chiral drug, the “right” chiral molecule of it causes relief from morning sickness and its “left” chiral molecule caused deformities in babies. Since the left chiral molecule was not separated from the right chiral molecule in thalidomide by the drug company, it resulted in huge effect to the babies inside the womb. The separation of chiral...