20th World Conference on Pharmaceutical Chemistry and Drug Design

             CHEMOINFORMATICS IN DRUG DISCOVERY & DEVELOPMENT Due to the complex structures of biomolecules which are responsible for disease such as AIDS, Cancer, Autism, Alzheimer etc. discovery of drugs still remains a challenging task for medical researchers. Due to changes in various factors which includes food habit, environmental and migration in human life style it has become mandatory in recent times to design and develop a drug without any side effects. Cheminformatics deals with discovering drugs based in modern drug discovery techniques which in turn rectifies complex issues in traditional drug discovery system. For better understanding of complex structures of chemical compounds cheminformatics tools are most prominent. Cheminformatics drug Discovery is a new emerging interdisciplinary field which primarily aims to discover Novel Chemical Entities which ultimately results in design of new molecule. It also plays an i...

                       Marine Pharmacology in Drug Discovery and Development New diseases are emerging due to the changes in the environments. Overburdened is created for the existing resources for the drugs due to enormous growth of world population. Though 75% of earth's surface is covered by water the research on pharmacology of marine organisms is limited and remained unexplored. Marine environment gives countless and diverse resources for the development of new drugs against cancer or malaria. The aquatic organisms are screened for antibacterial, immunomodulator, anti-fungal, anti-inflammatory, anticancer, antimicrobial, neuroprotective, analgesic, and antimalarial properties are used for the new drug developments throughout the world. Marine pharmacology offers the scope for research on Drugs Discovery and Development from marine origin. Marine pharmacology is a branch of pharmaceutical sciences which focuses o...

     DNA Drug Design for Cancer Therapy A direct genetic approach for cancer treatment is represented through DNA (antisense and other oligonucleotides (ODN’s)) drug design . This approach follows the mechanisms that activate genes known to confer a growth advantage to neoplastic cells. They have the ability to block the expression of these genes which allows exploration of normal growth regulation. As the Progress in DNA drug technology has been rapid, the traditional antisense inhibition of gene expression is now viewed on a genomic scale. Several antisense oligonucleotides are in clinical trials. These antisense oligonucleotides are well tolerated, and are potentially, therapeutically active. These drugs are promising molecular medicines for the treatment of human cancer in the near future. Antisense or decoy DNA drugs can specifically inhibit gene expression and, as indicated in this review, can ultimately affect abnormal cell proliferation. Downregulat...

     Nano-Technology in Drug Discovery  & Development                                                            The Technology which uses creation and utilization of materials, devices and systems through the control of matter on the nanometer scale is called Nano-technology. Impact on diagnostics and drug delivery is created by the application of nanotechnology in life sciences, nanobiotechnology. Now, researchers are started using Nano-technology (including nanoparticles and nanodevices such as Nano-biosensors and Nano-biochips) in the field of drug discovery and development. Nano-substances could be potential drugs for the future. Safety concerns, determining the nature and extent of adverse events of drugs are determined by the use of Nano-technology.Nanotechnology applications in healthcare and ...

Medicinal Chemistry Current Approaches to Drug Discovery for  Cancer and Tropical Diseases   The remarkable changes in technological and scientific developments in the past years have dramatically changed the pharmaceutical innovation process. Well-established strategies, such as high-throughput screening (HTS), have progressively been applied in association with novel techniques founded on genomics and proteomics , molecular and structural biology and molecular modeling. Altogether, these fields have provided outstanding advances for our comprehension of the fundamental cellular and molecular mechanisms of diseases in addition to enabling important progress in the technological arsenal used in drug discovery. Combined with novel methods in organic synthesis, such as combinatorial chemistry, the forefront approaches have built a novel paradigm in the research-based pharmaceutical industry. Evolving paradigm, which has its roots attached to the recent advances in med...

                                                         NATURAL PRODUCTS IN DRUG DISCOVERY PROCESS Natural products have historically been incredible as a source of therapeutic agents in curing many diseases. In last 10 years, research on natural products in the pharmaceutical field has reduced, owing to issues such as the lack of compatibility of traditional natural-product extract libraries with high-throughput screening. Recent techniques in genomics, proteomics and structural biology during the past few decades are giving a clearer picture of the diversity of proteins targeted by natural-product molecules. The current lead generation strategies have led to a renewed interest in natural products in drug discovery . There is need of drug discovery process and new drug designing techniques due to prevalence of many...

                                             4D-QSAR IN DRUG DESIGN Computational methods play a crucial role in modern medicinal chemistry , presenting a unique potential for transforming the early phases of drug research, particularly in terms of time and cost savings. Most of the techniques used in structure-based drug design have experienced significant improvements in the past few years, resulting in a remarkable enhancement of the speed and the efficacy of this approach. The successful application of 4D-QSAR models to generate 3D pharmacophores of ligand-receptor data sets, to analyze and design of virtual libraries, showing that it can be a powerful tool in the early stages of drug discovery process . 4D-QSAR analysis can also be applied to non-medicinal chemistry and bio...