20th World Conference on Pharmaceutical Chemistry and Drug Design

     Nano-Technology in Drug Discovery  & Development                                                            The Technology which uses creation and utilization of materials, devices and systems through the control of matter on the nanometer scale is called Nano-technology. Impact on diagnostics and drug delivery is created by the application of nanotechnology in life sciences, nanobiotechnology. Now, researchers are started using Nano-technology (including nanoparticles and nanodevices such as Nano-biosensors and Nano-biochips) in the field of drug discovery and development. Nano-substances could be potential drugs for the future. Safety concerns, determining the nature and extent of adverse events of drugs are determined by the use of Nano-technology.Nanotechnology applications in healthcare and ...

Medicinal Chemistry Current Approaches to Drug Discovery for  Cancer and Tropical Diseases   The remarkable changes in technological and scientific developments in the past years have dramatically changed the pharmaceutical innovation process. Well-established strategies, such as high-throughput screening (HTS), have progressively been applied in association with novel techniques founded on genomics and proteomics , molecular and structural biology and molecular modeling. Altogether, these fields have provided outstanding advances for our comprehension of the fundamental cellular and molecular mechanisms of diseases in addition to enabling important progress in the technological arsenal used in drug discovery. Combined with novel methods in organic synthesis, such as combinatorial chemistry, the forefront approaches have built a novel paradigm in the research-based pharmaceutical industry. Evolving paradigm, which has its roots attached to the recent advances in med...

                                                         NATURAL PRODUCTS IN DRUG DISCOVERY PROCESS Natural products have historically been incredible as a source of therapeutic agents in curing many diseases. In last 10 years, research on natural products in the pharmaceutical field has reduced, owing to issues such as the lack of compatibility of traditional natural-product extract libraries with high-throughput screening. Recent techniques in genomics, proteomics and structural biology during the past few decades are giving a clearer picture of the diversity of proteins targeted by natural-product molecules. The current lead generation strategies have led to a renewed interest in natural products in drug discovery . There is need of drug discovery process and new drug designing techniques due to prevalence of many...

                                             4D-QSAR IN DRUG DESIGN Computational methods play a crucial role in modern medicinal chemistry , presenting a unique potential for transforming the early phases of drug research, particularly in terms of time and cost savings. Most of the techniques used in structure-based drug design have experienced significant improvements in the past few years, resulting in a remarkable enhancement of the speed and the efficacy of this approach. The successful application of 4D-QSAR models to generate 3D pharmacophores of ligand-receptor data sets, to analyze and design of virtual libraries, showing that it can be a powerful tool in the early stages of drug discovery process . 4D-QSAR analysis can also be applied to non-medicinal chemistry and bio...

                                   APPROACHES IN PHARMACOVIGILANCE The importance of pharmacovigilance the ongoing assessment of the safety of a marketed medicine has been increasingly appreciated in recent years, owing in part to high-profile safety issues with widely used drugs. In response, strategies to improve the collection, integration and analysis of data related to post-marketing drug safety are being initiated or enhanced. The key tools that are available for pharmacovigilance are appropriate to use in different situations and consider the future directions of the field. Study designs used in pharmacovigilance Case reports and case series:   Case reports are concerned with single patients who have been exposed to a drug and experienced an adverse reaction. Case series can refer to a collection of patients who have been exposed to the same drug and whose clinical outco...

MOLECULAR MODELING IN PHARMACEUTICAL CHEMISTRY AND DRUG DESIGN Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. Drug design is a creative act of the same magnitude as composing, sculpting, or writing. Drug Design manually serves for the analysis of molecular structure and the correlation of these structures with pharmacological reactions . In understanding the three-dimensional aspects in the specificity of drug-receptor interactions at the molecular level Molecular modeling plays an important role. Opportunities has been created by Molecular modeling in assisting medicinal chemists in the design of new therapeutic agents. High-performance computing and graphics tools are brought within reach of most academic and industrial laboratories by the developments made in theoretical medicinal chemistry and computer hardware, facilitating the approaches for the development of rational drug design. ...

ADVANCEMENTS IN COMPUTER-AIDED DRUG DESIGN The research fields in chemical engineering have always been changing and evolving, from the field of applied industrial chemistry at the beginning of the last century, through the revolutionary reformulation of unit operations, transport phenomena and engineering science in the 1960s, to the extensive use of computing technology and the incorporation of molecular biology over the last two decades. Indeed, the integration of computational force and molecular biology, such as to simulate the behavior of molecules, is becoming a mainstream in the chemical engineering research and has received much attention from the pharmaceutical industries. The two major application areas of CADD, include structure-based drug design and ligand-based drug design. Structure-based drug design relies on three-dimensional knowledge of the receptor structure and its active sites to investigate interaction, binding energy and steric relationship betw...